Cyclin O Antikörper (N-Term)

Produktnummer ABIN6990651

Produktdetails anti-Cyclin O Antikörper

Target: Cyclin O (CCNO)

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin O Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Spezifität: At least two isoforms of Cyclin O are known to exist, this antibody will recognize both isoforms.

Aufreinigung: Cyclin O Antibody is affinity chromatography purified via peptide column.

Immunogen: Cyclin O antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human Cyclin O. The immunogen is located within the first 50 amino acids of Cyclin O.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Cyclin O antibody can be used for the detection of Cyclin O by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Cyclin O Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: Cyclin O antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu Cyclin O

Target: Cyclin O (CCNO)

Andere Bezeichnung: Cyclin O (CCNO Produkte)

Hintergrund: Cyclin O Antibody: Cyclin O, also known as CCNO, has recently been identified as a Cdk1- and Cdk2-activating cyclin specific to apoptosis in lymphoid cells. Cyclin O binds to and activates Cdk2 in response to instrinsic apoptotic stimuli such as glucocorticoids or DNA-damaging agents. Supression of Cyclin O expression by shRNA leads to the inhibition of glucocorticoid and DNA-damage-induced apoptosis due to a failure of apical caspase activation while leaving the CD95 death receptor-mediated apoptosis intact. Note: this gene, which had a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase. A later publication identified this gene's product as a cyclin protein family member.

Molekulargewicht: 39 kDa

Gen-ID: 10309

NCBI Accession: NP_066970

UniProt: P22674