SLUG Antikörper (AA 90-140)
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- Target Alle SLUG Produkte
- SLUG
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Bindungsspezifität
- AA 90-140
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser SLUG Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunofluorescence (IF)
- Spezifität
- This Slug antibody is predicted to not cross-react with Snail.
- Aufreinigung
- Slug Antibody is affinity chromatography purified via peptide column.
- Immunogen
- Slug antibody was raised against a 13 amino acid synthetic peptide from near the center of human Slug. The immunogen is located within amino acids 90 - 140 of Slug.
- Isotyp
- IgG
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- Applikationshinweise
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Slug antibody can be used for detection of Slug by Western blot at 0.5 μ,g/mL. Antibody can also be used for immunofluorescence starting at 20 μ,g/mL.
Antibody validated: Western Blot in human and mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Slug Antibody is supplied in PBS containing 0.02 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,4 °C
- Informationen zur Lagerung
- Slug antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Target
- SLUG
- Abstract
- SLUG Produkte
- Synonyme
- Slug antikoerper, Slugh antikoerper, Snail2 antikoerper, SLUG antikoerper, SLUGH antikoerper, SLUGH1 antikoerper, SNAIL2 antikoerper, WS2D antikoerper, snail family zinc finger 2 antikoerper, snail family transcriptional repressor 2 antikoerper, Snai2 antikoerper, SNAI2 antikoerper
- Hintergrund
- Slug Antibody: Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, was initially identified to be involved in epithelial-mesenchymal transitions as well as the formation of the neural tube during vertebrate embryogenesis. Like Snail, Slug transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Once expressed, Slug will bind E-box regions of promoters and repress transcription of genes such as E-cadherin and Claudin-. More recently, its expression in breast, esophogeal, and colorectal carcinomas has been correlated with poor prognosis for survival. Furthermore, Slug can protect hemapoietic progenitor cells from radiation-induced apoptosis by repressing the p53-mediated transcription of Puma, a BH3-only antagonist of the anti-apoptotic members of the Bcl-2 family.
- Molekulargewicht
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Predicted: 29 kDa
Observed: 30 kDa - Gen-ID
- 6591
- UniProt
- O43623
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