NPAS3 Antikörper (N-Term)
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- Target Alle NPAS3 Antikörper anzeigen
- NPAS3 (Neuronal PAS Domain Protein 3 (NPAS3))
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Bindungsspezifität
- AA 40-90, N-Term
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser NPAS3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
- Aufreinigung
- NPAS3 Antibody is affinity chromatography purified via peptide column.
- Immunogen
- NPAS3 antibody was raised against a 28 amino acid synthetic peptide from near the amino terminus of human NPAS3. The immunogen is located within amino acids 40 - 90 of NPAS3.
- Isotyp
- IgG
- Top Product
- Discover our top product NPAS3 Primärantikörper
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- Applikationshinweise
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NPAS3 antibody can be used for detection of NPAS3 by Western blot at 0.5 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- NPAS3 Antibody is supplied in PBS containing 0.02 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C,4 °C
- Informationen zur Lagerung
- NPAS3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- Target
- NPAS3 (Neuronal PAS Domain Protein 3 (NPAS3))
- Andere Bezeichnung
- NPAS3 (NPAS3 Produkte)
- Synonyme
- trh antikoerper, mop6 antikoerper, pasd6 antikoerper, MGC145768 antikoerper, MOP6 antikoerper, PASD6 antikoerper, bHLHe12 antikoerper, 4930423H22Rik antikoerper, neuronal PAS domain protein 3 antikoerper, npas3 antikoerper, NPAS3 antikoerper, Npas3 antikoerper
- Hintergrund
- NPAS3 Antibody: Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor and is broadly expressed in the developing neuroepithelium and has recently found to be disrupted by genetic translocation in a family affected with schizophrenia. It was recently shown to be involved in the regulation of FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1 and in turn neurogenesis emanating from this region. NPAS3-null mice were growth-retarded and displayed brain defects that included reduced size of the anterior hippocampus, hypoplasia of the corpus callosum, and enlargement of the ventricles, as well as several behavioral abnormalities. Furthermore, these NPAS3-null mice also exhibited disruptions in several neurosignaling pathways involving glutamate, dopamine, and serotonin. These results demonstrate the essential role played by NPAS3 during structural and functional brain development. At least three isoforms of NPAS3 are known to exist.
- Gen-ID
- 64067
- UniProt
- Q8IXF0
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