HAP1 Antikörper (AA 310-360)

Produktnummer ABIN6990748

Produktdetails anti-HAP1 Antikörper

Target: HAP1 (Huntingtin Associated Protein 1 (HAP1))

Bindungsspezifität: AA 310-360

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: HAP1 Antibody is affinity chromatography purified via peptide column.

Immunogen: HAP1 antibody was raised against a 19 amino acid synthetic peptide from near the center of human HAP1. The immunogen is located within amino acids 310 - 360 of HAP1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: HAP1 antibody can be used for detection of HAP1 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: HAP1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: HAP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu HAP1

Target: HAP1 (Huntingtin Associated Protein 1 (HAP1))

Andere Bezeichnung: HAP1 (HAP1 Produkte)

Synonyme: HAP2 antikoerper, HIP5 antikoerper, HLP antikoerper, hHLP1 antikoerper, HAP1-A antikoerper, HAP1-B antikoerper, HAP-1 antikoerper, huntingtin associated protein 1 antikoerper, huntingtin-associated protein 1 antikoerper, HAP1 antikoerper, Hap1 antikoerper

Hintergrund: HAP1 Antibody: Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. HAP1 was initially identified through a two-hybrid library screening, the binding of HAP1 to huntingtin correlated with the expansion of the polyglutamine tract. HAP1 also interacts with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), suggesting that HAP1 may play a role in vesicular trafficking or organelle transport. HAP1 is also involved with the huntingtin-enhanced BDNF transport along the cellular microtubles. Attenuation of this process led to the loss of neurotrophic support and neuronal toxicity, which suggests that loss of this function might contribute to pathogenesis. Several alternatively spliced isoforms have been described for HAP1.

Gen-ID: 9001

UniProt: P54257

Pathways: Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus