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UIMC1 Antikörper (C-Term)

UIMC1 Reaktivität: Human, Maus WB, ELISA, IF, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6990792
  • Target Alle UIMC1 Antikörper anzeigen
    UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
    Bindungsspezifität
    • 6
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 520-570, C-Term
    Reaktivität
    • 31
    • 7
    • 5
    Human, Maus
    Wirt
    • 28
    • 2
    • 1
    Kaninchen
    Klonalität
    • 31
    Polyklonal
    Konjugat
    • 21
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser UIMC1 Antikörper ist unkonjugiert
    Applikation
    • 18
    • 8
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    RAP80 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    RAP80 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human RAP80. The immunogen is located within amino acids 520 - 570 of RAP80.
    Isotyp
    IgG
    Top Product
    Discover our top product UIMC1 Primärantikörper
  • Applikationshinweise
    RAP80 antibody can be used for detection of RAP80 by Western blot at 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    RAP80 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    RAP80 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
    Andere Bezeichnung
    RAP80 (UIMC1 Produkte)
    Synonyme
    UIMC1 antikoerper, RAP80 antikoerper, X2HRIP110 antikoerper, 9430016E08Rik antikoerper, D330018D10Rik antikoerper, D630032M02Rik antikoerper, RIP110 antikoerper, Rxrip110 antikoerper, RGD1307009 antikoerper, ubiquitin interaction motif containing 1 antikoerper, UIMC1 antikoerper, Uimc1 antikoerper
    Hintergrund
    RAP80 Antibody: RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist.
    Gen-ID
    51720
    UniProt
    Q96RL1
    Pathways
    DNA Reparatur, Nuclear Hormone Receptor Binding, Positive Regulation of Response to DNA Damage Stimulus
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