VPS53 Antikörper (AA 390-440)

Produktnummer ABIN6990901

Produktdetails anti-VPS53 Antikörper

Target: VPS53 (Vacuolar Protein Sorting 53 Homolog (VPS53))

Bindungsspezifität: AA 390-440

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser VPS53 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: VPS53 Antibody is affinity chromatography purified via peptide column.

Immunogen: VPS53 antibody was raised against a 18 amino acid synthetic peptide from near the center of human VPS53. The immunogen is located within amino acids 390 - 440 of VPS53.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: VPS53 antibody can be used for detection of VPS53 by Western blot at 0.5 - 1 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: VPS53 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: VPS53 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu VPS53

Target: VPS53 (Vacuolar Protein Sorting 53 Homolog (VPS53))

Andere Bezeichnung: VPS53 (VPS53 Produkte)

Hintergrund: VPS53 Antibody: The sorting of acid hydrolases to lysosomes rely on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintenance of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins. VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in HIV treatment. At least five isoforms of VPS53 are known to exist.

Gen-ID: 55275

UniProt: Q5VIR6