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SPG11 Antikörper (C-Term)

SPG11 Reaktivität: Human, Maus, Ratte ELISA, WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6991060
  • Target Alle SPG11 Antikörper anzeigen
    SPG11 (Spastic Paraplegia 11 (Autosomal Recessive) (SPG11))
    Bindungsspezifität
    AA 2360-2410, C-Term
    Reaktivität
    Human, Maus, Ratte
    Wirt
    • 5
    • 2
    Kaninchen
    Klonalität
    • 7
    Polyklonal
    Konjugat
    • 3
    • 2
    • 1
    • 1
    Dieser SPG11 Antikörper ist unkonjugiert
    Applikation
    ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    SPG11 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    SPG11 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human SPG11. The immunogen is located within amino acids 2360 - 2410 of SPG11.
    Isotyp
    IgG
    Top Product
    Discover our top product SPG11 Primärantikörper
  • Applikationshinweise
    SPG11 antibody can be used for detection of SPG11 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

    Antibody validated: Western Blot in mouse samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    SPG11 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    SPG11 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    SPG11 (Spastic Paraplegia 11 (Autosomal Recessive) (SPG11))
    Andere Bezeichnung
    SPG11 (SPG11 Produkte)
    Synonyme
    6030465E24Rik antikoerper, A330015I11 antikoerper, C530005A01Rik antikoerper, KIAA1840 antikoerper, RGD1562529 antikoerper, SPG11, spatacsin vesicle trafficking associated antikoerper, Spg11 antikoerper, SPG11 antikoerper
    Hintergrund
    SPG11 Antibody: Hereditary spastic paraplegias (HSPs) are genetically and phenotypically heterogeneous disorders.  Spastic paraplegia with thinning of the corpus callosum (ARHSP-TCC) is a relatively frequent form of complicated hereditary spastic paraplegia (cHSP) in which mental retardation and muscle stiffness at onset are followed by slowly progressive paraparesis and cognitive deterioration. Mutations of the SPG11 gene encoding the spatacsin protein have been identified as a major cause of HSP-TCC. Spatacsin is a potential transmembrane protein that is phosphorylated upon DNA damage. It is expressed in all structures of the brain, with a high expression in the cerebellum. SPG11 mutations may occur more frequently in familial than sporadic forms of cHSP without TCC. Kjellin syndrome is found to be associated with mutations in not only the SPG15 gene but also SPG11 gene.  Recent studies show Parkinsonism may initiate SPG11-linked HSP TCC and that SPG11 may cause juvenile Parkinsonism.
    Gen-ID
    80208
    UniProt
    Q96JI7
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