SIPA1L1 Antikörper (N-Term)

Produktnummer ABIN6991227

Produktdetails anti-SIPA1L1 Antikörper

Target: SIPA1L1 (Signal-Induced Proliferation-Associated 1 Like 1 (SIPA1L1))

Bindungsspezifität: AA 40-90, N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIPA1L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Aufreinigung: SIPA1L1 Antibody is affinity chromatography purified via peptide column.

Immunogen: SIPA1L1 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human SIPA1L1. The immunogen is located within amino acids 40 - 90 of SIPA1L1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: SIPA1L1 antibody can be used for detection of SIPA1L1 by Western blot at 0.5 - 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: SIPA1L1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: SIPA1L1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu SIPA1L1

Target: SIPA1L1 (Signal-Induced Proliferation-Associated 1 Like 1 (SIPA1L1))

Andere Bezeichnung: SIPA1L1 (SIPA1L1 Produkte)

Synonyme: 4931426N11Rik antikoerper, AW213287 antikoerper, Spar antikoerper, mKIAA0440 antikoerper, SPAL antikoerper, Spa-1 antikoerper, Spa1 antikoerper, E6TP1 antikoerper, cb600 antikoerper, id:ibd5092 antikoerper, sb:cb600 antikoerper, si:ch211-106p8.1 antikoerper, wu:fc43g06 antikoerper, signal induced proliferation associated 1 like 1 antikoerper, signal-induced proliferation-associated 1 like 1 antikoerper, SIPA1L1 antikoerper, sipa1l1 antikoerper, Sipa1l1 antikoerper

Hintergrund: SIPA1L1 Antibody: Signal-induced proliferation associated-like protein 1 (SIPA1L1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.

Gen-ID: 26037

NCBI Accession: NP_056371

UniProt: O43166