EFHD2 Antikörper (N-Term)

Produktnummer ABIN6991298

Produktdetails anti-EFHD2 Antikörper

Target: EFHD2 (EF-Hand Domain Family, Member D2 (EFHD2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EFHD2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Aufreinigung: EFHD2 Antibody is affinity chromatography purified via peptide column.

Immunogen: EFHD2 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human EFHD2. The immunogen is located within the first 50 amino acids of EFHD2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: EFHD2 antibody can be used for detection of EFHD2 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: EFHD2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: EFHD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Referenzen für anti-EFHD2 Antikörper (ABIN6991298)

ODonnell, Dagley, Curley, Darbey, OShaughnessy, Diemer, Pilatz, Fietz, Stanton, Smith, Rebourcet: "Sertoli cell-enriched proteins in mouse and human testicular interstitial fluid." in: PloS one, Vol. 18, Issue 9, pp. e0290846, (2023) (PubMed).

Details zu EFHD2

Target: EFHD2 (EF-Hand Domain Family, Member D2 (EFHD2))

Andere Bezeichnung: EFHD2 (EFHD2 Produkte)

Synonyme: SWS1 antikoerper, efhd2 antikoerper, EFHD2 antikoerper, MGC131292 antikoerper, 2600015J22Rik antikoerper, AA408606 antikoerper, D4Wsu27e antikoerper, si:dkey-72l14.9 antikoerper, wu:fb80e07 antikoerper, EF-hand domain family member D2 antikoerper, EF-hand domain family, member D2 antikoerper, EF-hand domain family member D2 L homeolog antikoerper, EF hand domain containing 2 antikoerper, EFHD2 antikoerper, Efhd2 antikoerper, efhd2 antikoerper, efhd2.L antikoerper

Hintergrund: EFHD2 Antibody: EFHD2, also known as Swiprosin-1 or SWS1, is an EF-hand and coiled-coil-containing adaptor protein that plays a role in lymphocyte physiology. EFHD2 exhibits the highest expression in CD8+ T cells and immature B cells. It provides a membrane scaffold that is required for the Syk-, SLP-65-, and PLCgamma2-dependent B-cell receptor (BCR)-induced calcium flux. EFHD2 may also regulate BCR-induced immature and primary B-cell apoptosis. It controls spontaneous apoptosis through the regulation of BCL2L1 abundance. Also, EFHD2 plays a role as negative regulator of the canonical NF-κ,B-activating branch.

Gen-ID: 79180

NCBI Accession: NP_077305

UniProt: Q96C19