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CXXC4 Antikörper (N-Term)

CXXC4 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC (p), IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6991438
  • Target Alle CXXC4 Antikörper anzeigen
    CXXC4 (CXXC Finger Protein 4 (CXXC4))
    Bindungsspezifität
    • 10
    • 8
    • 7
    • 2
    • 2
    • 1
    AA 50-100, N-Term
    Reaktivität
    • 22
    • 13
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 21
    • 1
    Kaninchen
    Klonalität
    • 22
    Polyklonal
    Konjugat
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser CXXC4 Antikörper ist unkonjugiert
    Applikation
    • 21
    • 16
    • 15
    • 14
    • 3
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Aufreinigung
    CXXC4 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    CXXC4 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CXXC4. The immunogen is located within amino acids 50 - 100 of CXXC4.
    Isotyp
    IgG
    Top Product
    Discover our top product CXXC4 Primärantikörper
  • Applikationshinweise
    CXXC4 antibody can be used for detection of CXXC4 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 10 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    CXXC4 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    CXXC4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    CXXC4 (CXXC Finger Protein 4 (CXXC4))
    Andere Bezeichnung
    CXXC4 (CXXC4 Produkte)
    Synonyme
    9330210J02Rik antikoerper, C030003J12Rik antikoerper, Idax antikoerper, IDAX antikoerper, Xldax antikoerper, xIdax antikoerper, CXXC finger 4 antikoerper, CXXC finger protein 4 antikoerper, CXXC finger protein 4 S homeolog antikoerper, Cxxc4 antikoerper, CXXC4 antikoerper, cxxc4.S antikoerper
    Hintergrund
    CXXC4 Antibody: CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.
    Gen-ID
    80319
    NCBI Accession
    NP_079488
    UniProt
    Q9H2H0
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