TYW1 Antikörper (C-Term)

Produktnummer ABIN6991540

Produktdetails anti-TYW1 Antikörper

Target: TYW1 (tRNA-YW Synthesizing Protein 1 Homolog (TYW1))

Bindungsspezifität: AA 520-570, C-Term

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TYW1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: TYW1 antibody is predicted to not cross-react with other TYW protein family members. At least three isoforms of TYW1 are known to exist, this antibody will only detect the two larger isoforms.

Aufreinigung: TYW1 Antibody is affinity chromatography purified via peptide column.

Immunogen: TYW1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human TYW1. The immunogen is located within amino acids 520 - 570 of TYW1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TYW1 antibody can be used for detection of TYW1 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TYW1 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: TYW1 antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu TYW1

Target: TYW1 (tRNA-YW Synthesizing Protein 1 Homolog (TYW1))

Andere Bezeichnung: TYW1 (TYW1 Produkte)

Synonyme: RSAFD1 antikoerper, TYW1A antikoerper, YPL207W antikoerper, RGD1310420 antikoerper, Rsafd1 antikoerper, AW125391 antikoerper, im:6898509 antikoerper, wu:fb74d01 antikoerper, zgc:153368 antikoerper, tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) antikoerper, S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase antikoerper, tRNA-yW synthesizing protein 1 homolog S homeolog antikoerper, tRNA-yW synthesizing protein 1 homolog antikoerper, TYW1 antikoerper, LOC100354908 antikoerper, tyw1.S antikoerper, Tyw1 antikoerper, tyw1 antikoerper

Hintergrund: TYW1 Antibody: TYW1, also known as TYW1A, RSAFD1 or YPL207W, is a 732 amino acid protein containing one flavodoxin-like domain that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW1 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW1 binds to one 4Fe-4S cluster and is located on human chromosome 7. Defects in some of the genes on chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome, suggesting that TYW1 may play a role in these conditions

Gen-ID: 55253

NCBI Accession: NP_060734

UniProt: Q9NV66