SIGLEC15 Antikörper (N-Term)

Produktnummer ABIN6991662

Produktdetails anti-SIGLEC15 Antikörper

Target: SIGLEC15 (Sialic Acid Binding Ig-Like Lectin 15 (SIGLEC15))

Bindungsspezifität: AA 50-100, N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIGLEC15 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: SIGLEC15 antibody is predicted to not cross-react with other SIGLEC family members.

Aufreinigung: SIGLEC15 Antibody is affinity chromatography purified via peptide column.

Immunogen: SIGLEC15 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human SIGLEC15. The immunogen is located within amino acids 50 - 100 of SIGLEC15.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: SIGLEC15 antibody can be used for detection of SIGLEC15 by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: SIGLEC15 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: SIGLEC15 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu SIGLEC15

Target: SIGLEC15 (Sialic Acid Binding Ig-Like Lectin 15 (SIGLEC15))

Andere Bezeichnung: SIGLEC15 (SIGLEC15 Produkte)

Synonyme: RGD1565948 antikoerper, CD33L3 antikoerper, HsT1361 antikoerper, SIGLEC-15 antikoerper, Cd33l3 antikoerper, EG620235 antikoerper, SIGLEC-I antikoerper, sialic acid binding Ig-like lectin 15 antikoerper, sialic acid binding Ig like lectin 15 antikoerper, Siglec15 antikoerper, SIGLEC15 antikoerper

Hintergrund: SIGLEC15 Antibody: Siglecs are vertebrate cell-surface lectins that recognize sialylated glycans and are involved in many physiological processes, such as glycoprotein turnover, cellular trafficking, and pathogen recognition. Most Siglecs are expressed on cells of the immune system. SIGLEC15 is a type-I transmembrane protein consisting of two immunoglobulin (Ig)-like domains, a transmembrane domain containing a lysine residue, and a short cytoplasmic tail. SIGLEC15 can interact with the activating adaptor molecules DAP12/10. Its activating signaling potential and unique preference for glycan recognition implies that SIGLEC15 may be involved in the immune surveillance of tumors and probably plays a conserved, regulatory role in the immune system of vertebrates.

Molekulargewicht: Predicted: 36 kDa

Observed: 42 kDa

Gen-ID: 284266

NCBI Accession: NP_998767

UniProt: Q6ZMC9