At least four isoforms of TTYH2 are known to exist, this antibody will only detect the two longest isoforms. This antibody is predicted to not cross-react with other TTYH family members.
Aufreinigung
TTYH2 Antibody is affinity chromatography purified via peptide column.
Immunogen
TTYH2 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human TTYH2. The immunogen is located within amino acids 60 - 110 of TTYH2.
TTYH2
Reaktivität: Human
Wirt: Kaninchen
Polyclonal
FITC
Applikationshinweise
TTYH2 antibody can be used for detection of TTYH2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μ,g/mL. For immunofluorescence start at 2.5 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
1 mg/mL
Buffer
TTYH2 Antibody is supplied in PBS containing 0.02 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C,4 °C
Informationen zur Lagerung
TTYH2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
RGD1562969 antikoerper, C17orf29 antikoerper, 1110001A03Rik antikoerper, tweety family member 2 antikoerper, tweety family member 2 S homeolog antikoerper, Ttyh2 antikoerper, TTYH2 antikoerper, ttyh2.S antikoerper
Hintergrund
TTYH2 Antibody: TTYH2 is a member of the tweety family of proteins, a family of chloride anion channels containing five transmembrane regions. TTYH2 is a Ca2+-activated large conductance chloride (Cl-) channel and may play a role in kidney tumorigenesis. It is also upregulated in colon carcinoma and is thought to play a role in cell proliferation and call aggregation, suggesting that TTYH2 may play a role in regulating both proliferation and metastatic potentials of colorectal cancer. The ubiquitin-protein ligase Nedd4-2 binds to and ubiquitinates TTYH2, thereby regulating its cell surface expression and total cellular levels.