CISD2 Antikörper (AA 40-90)

Produktnummer ABIN6991848

Produktdetails anti-CISD2 Antikörper

Target: CISD2 (CDGSH Iron Sulfur Domain 2 (CISD2))

Bindungsspezifität: AA 40-90

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CISD2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: CISD2 Antibody is affinity chromatography purified via peptide column.

Immunogen: CISD2 antibody was raised against a 15 amino acid peptide near the center of human CISD2. The immunogen is located within amino acids 40 - 90 of CISD2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: CISD2 antibody was raised against a 15 amino acid peptide near the center of human CISD2.

Antibody validated: Western Blot in rat samples, Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: CISD2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: CISD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu CISD2

Target: CISD2 (CDGSH Iron Sulfur Domain 2 (CISD2))

Andere Bezeichnung: CISD2 (CISD2 Produkte)

Synonyme: ERIS antikoerper, Miner1 antikoerper, NAF-1 antikoerper, WFS2 antikoerper, ZCD2 antikoerper, 1500009M05Rik antikoerper, 1500026J14Rik antikoerper, 1500031D15Rik antikoerper, AI848398 antikoerper, B630006A20Rik antikoerper, Noxp70 antikoerper, Zcd2 antikoerper, RGD1566242 antikoerper, zgc:64148 antikoerper, eris antikoerper, miner1 antikoerper, wfs2 antikoerper, zcd2 antikoerper, cisd2 antikoerper, BcDNA:RE49709 antikoerper, Dmel\\CG1458 antikoerper, CDGSH iron sulfur domain 2 antikoerper, CDGSH iron sulfur domain 2 L homeolog antikoerper, CDGSH iron sulfur domain 2 S homeolog antikoerper, CISD2 antikoerper, Cisd2 antikoerper, cisd2 antikoerper, cisd2.L antikoerper, cisd2.S antikoerper

Hintergrund: CISD2 Antibody: Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.

Molekulargewicht: Predicted: 15 kDa

Observed: 15 kDa

Gen-ID: 493856

NCBI Accession: NP_001008389

UniProt: Q8N5K1

Pathways: Activation of Innate immune Response