Arylsulfatase B Antikörper (C-Term)

Produktnummer ABIN6991898

Produktdetails anti-Arylsulfatase B Antikörper

Target: Arylsulfatase B (ARSB)

Bindungsspezifität: AA 460-510, C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Arylsulfatase B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Spezifität: ARSB antibody is human, mouse and rat reactive. At least two isoforms of ARSB are known to exist, this antibody only recognizes the longest isoform.

Aufreinigung: ARSB Antibody is affinity chromatography purified via peptide column.

Immunogen: ARSB antibody was raised against a 16 amino acid peptide near the carboxy terminus of human ARSB. The immunogen is located within amino acids 460 - 510 of ARSB .

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ARSB antibody can be used for detection of ARSB by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in mouse samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: ARSB Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: ARSB antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu Arylsulfatase B

Target: Arylsulfatase B (ARSB)

Andere Bezeichnung: ARSB (ARSB Produkte)

Hintergrund: Aryl sulfatase B (ARSB) forms a homodimer that hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate (1). ARSB localizes to the lysozyme as well as to the extracellular matrix (2). Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B (3), and can be treated with exogenous ARSB (4).

Molekulargewicht: Predicted: 59 kDa

Observed: 57kDa

Gen-ID: 411

NCBI Accession: NP_000037

UniProt: P15848

Pathways: Glycosaminoglycan Metabolic Process