PHC3 Antikörper (N-Term)

Produktnummer ABIN6991943

Produktdetails anti-PHC3 Antikörper

Target: PHC3 (Polyhomeotic Homolog 3 (PHC3))

Bindungsspezifität: AA 240-290, N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PHC3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: PHC3 antibody is human, mouse and rat specific. At least six isoforms of PHC3 are known to exist.

Aufreinigung: PHC3 antibody is affinity chromatography purified via peptide column.

Immunogen: PHC3 antibody was raised against a 19 amino acid peptide near the amino terminus of human PHC3. The immunogen is located within amino acids 240 - 290 of PHC3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: PHC3 antibody can be used for detection of PHC3 by Western blot at 1 - 2 μ,g/mL.

Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PHC3 antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: PHC3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu PHC3

Target: PHC3 (Polyhomeotic Homolog 3 (PHC3))

Andere Bezeichnung: PHC3 (PHC3 Produkte)

Synonyme: EDR3 antikoerper, HPH3 antikoerper, E030046K01Rik antikoerper, Edr3 antikoerper, Hph3 antikoerper, polyhomeotic homolog 3 antikoerper, polyhomeotic-like 3 (Drosophila) antikoerper, Phc3 antikoerper, PHC3 antikoerper

Hintergrund: Polycomb group (PcG) proteins assemble into multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes throughout development (1). PHC3 (Polyhomeotic-like protein 3), also known as Early development regulatory protein 3, is a 983 amino acid nuclear protein that is a component of the PcG multiprotein PRC1 complex (2). PRC1 complex acts via chromatin remodeling and modification of histones. PHC3 contains 1 FCS-type zinc finger and SAM (sterile alpha motif) domain (2-3). PHC 3 has been regarded as a candidate tumor suppressor of osteosarcoma (4).

Molekulargewicht: Predicted: 109 kDa

Observed: 120 kDa

Gen-ID: 80012

NCBI Accession: NP_079223

UniProt: Q8NDX5