ATM Interactor Antikörper (N-Term)

Produktnummer ABIN6991999

Produktdetails anti-ATM Interactor Antikörper

Target: ATM Interactor (ATMIN)

Bindungsspezifität: AA 200-250, N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATM Interactor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: ATMIN antibody is human, mouse and rat reactive. At least three isoforms of ATMIN are known to exist.

Aufreinigung: ATMIN antibody is affinity chromatography purified via peptide column.

Immunogen: ATMIN antibody was raised against a 19 amino acid peptide near the amino terminus of human ATMIN. The immunogen is located within amino acids 200 - 250 of ATMIN.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ATMIN antibody can be used for detection of ATMIN by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for Immunocytochemistry at 5 μ,g/mL. For Immunoflorescence start at 2.5 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: ATMIN Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: ATMIN antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu ATM Interactor

Target: ATM Interactor (ATMIN)

Andere Bezeichnung: ATMIN (ATMIN Produkte)

Hintergrund: The ATM/ATR-substrate CHK2-interacting zinc finger protein (ATMIN), also known as ASCIZ, forms DNA damage-induced nuclear foci that contain the DNA repair protein Rad51 (1). ATMIN is also thought to be involved in embryonic development, as an absence of ATMIN causes late-embryonic lethality in mice with a range of organ development defects (2). It also activates the transcription DYNLL1, a light chain of the dynein motor complex and sequence-specific regulator of protein dimerization of numerous targets. DYNLL1 can bind to and inhibit the transcription activation domain of ATMIN, forming a simple dynamic feedback loop for DYNLL1 expression (3).

Molekulargewicht: Predicted: 73, 79, 91 kDa

Observed: 72 kDa

Gen-ID: 23300

NCBI Accession: NP_056066

UniProt: O43313