tau Antikörper (N-Term)

Produktnummer ABIN6992098

Produktdetails anti-tau Antikörper

Target: tau (tau Protein)

Bindungsspezifität: AA 210-260, N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser tau Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: TAU antibody is human, mouse and rat reactive. Multiple isoforms of TAU are known to exist, this antibody will only detect the two longest isoforms.

Aufreinigung: TAU antibody is affinity chromatography purified via peptide column.

Immunogen: TAU antibody was raised against a 19 amino acid peptide near the amino terminus of human TAU. The immunogen is located within amino acids 210 - 260 of TAU.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: TAU antibody can be used for detection of TAU by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human and rat samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: TAU antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: TAU antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu tau

Target: tau (tau Protein)

Andere Bezeichnung: TAU (tau Produkte)

Synonyme: DDPAC antikoerper, FTDP-17 antikoerper, MAPTL antikoerper, MSTD antikoerper, MTBT1 antikoerper, MTBT2 antikoerper, PPND antikoerper, TAU antikoerper, tau antikoerper, PHF-tau antikoerper, microtubule associated protein tau antikoerper, MAPT antikoerper

Hintergrund: The microtubial-associated protein TAU (MAPT), more commonly known as TAU, is is normally a highly soluble protein found predominantly in neurons (1), but accumulations of highly phosphorylated tau protein aggregates are observed in several neurodegenerative diseases including Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and frontotemporal lobar dementia. It was thought that these pathological tau aggregates were the toxic form of tau, but recent studies indicate that soluble and highly phosphorylated tau species are more closely associated with synaptic dysfunction and cell loss (2,3). Mutations in the TAU gene have also been associated with several of these neurodegenerative diseases (4).

Molekulargewicht: Predicted: 83 kDa

Observed: 90 kDa

Gen-ID: 4137

NCBI Accession: NP_058519

UniProt: P10636