ARID1A Antikörper (N-Term)

Produktnummer ABIN6992134

Produktdetails anti-ARID1A Antikörper

Target: ARID1A (AT Rich Interactive Domain 1A (SWI-Like) (ARID1A))

Bindungsspezifität: AA 580-630, N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ARID1A Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: ARID1A antibody is human, mouse and rat reactive. Multiple isoforms of ARID1A protein are known to exist.

Aufreinigung: ARID1A antibody is affinity chromatography purified via peptide column.

Immunogen: ARID1A antibody was raised against an 18 amino acid peptide near the amino terminus of human ARID1A. The immunogen is located within amino acids 580 - 630 of ARID1A.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ARID1A antibody can be used for detection of ARID1A by Western blot at 1 - 2 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples, Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: ARID1A antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: ARID1A antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu ARID1A

Target: ARID1A (AT Rich Interactive Domain 1A (SWI-Like) (ARID1A))

Andere Bezeichnung: ARID1A (ARID1A Produkte)

Synonyme: B120 antikoerper, BAF250 antikoerper, BAF250a antikoerper, BM029 antikoerper, C1orf4 antikoerper, ELD antikoerper, MRD14 antikoerper, OSA1 antikoerper, P270 antikoerper, SMARCF1 antikoerper, hELD antikoerper, hOSA1 antikoerper, 1110030E03Rik antikoerper, Osa1 antikoerper, Smarcf1 antikoerper, ARID1A antikoerper, wu:fb79b07 antikoerper, wu:fb95g08 antikoerper, zgc:171438 antikoerper, AT-rich interaction domain 1A antikoerper, AT rich interactive domain 1A (SWI-like) antikoerper, AT rich interactive domain 1Aa (SWI-like) antikoerper, ARID1A antikoerper, Arid1a antikoerper, arid1a antikoerper, arid1aa antikoerper

Hintergrund: The ARID1A protein is a member of the SWI/SNF family, whose members are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. ARID1A is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin (1). It possesses a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. The C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that ARID1A confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions (2).

Molekulargewicht: Predicted: 133, 227, 251 kDa

Observed: 130, 260 kDa

Gen-ID: 8289

NCBI Accession: NP_006006

UniProt: O14497

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Tube Formation