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SARS-CoV-2 ORF3a Antikörper (N-Term)

Reaktivität: SARS Coronavirus-2 (SARS-CoV-2) ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6992301
  • Target Alle SARS-CoV-2 ORF3a Produkte
    SARS-CoV-2 ORF3a
    Bindungsspezifität
    • 2
    • 1
    N-Term
    Reaktivität
    SARS Coronavirus-2 (SARS-CoV-2)
    Wirt
    • 2
    • 1
    Kaninchen
    Klonalität
    • 3
    Polyklonal
    Konjugat
    • 3
    Dieser SARS-CoV-2 ORF3a Antikörper ist unkonjugiert
    Applikation
    ELISA, Immunohistochemistry (IHC)
    Aufreinigung
    SARS-CoV-2 (COVID-19) ORF3a Antibody is affinity chromatography purified via peptide column.
    Immunogen
    Anti-SARS-CoV-2 (COVID-19) ORF3a antibody was raised against a peptide corresponding to 15 amino acids near the amino-terminus of SARS-CoV-2 (COVID-19) ORF3a protein. The immunogen is located within the first 50 amino acids of the SARS-CoV-2 (COVID-19) ORF3a protein.
    Isotyp
    IgG
  • Applikationshinweise
    IHC: 0.2 μ,g/mL Antibody validated: Immunohistochemistry in human samples. Antibody validated: SARS-CoV-2 (COVID-19) ORF3a antibody can detect 2 ng of free peptide at 1 μ,g/mL in ELISA. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    SARS-CoV-2 (COVID-19) ORF3a antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    SARS-CoV-2 (COVID-19) ORF3a antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    SARS-CoV-2 ORF3a
    Abstract
    SARS-CoV-2 ORF3a Produkte
    Synonyme
    ORF3a protein antikoerper, ORF3a antikoerper
    Substanzklasse
    Viral Protein
    Hintergrund
    Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1). The disease is the cause of the 2019-20 coronavirus outbreak (2). SARS-CoV-2 virus proteins include structural proteins, non-structural proteins and accessory factors. The structure of SARS-CoV-2 consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. SARS-CoV-2 non-structural protein is ORF1ab that consists of 16 proteins (nsp1-nsp16), while accessory factors include ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8, ORF9b, ORF9c and ORF10. ORF3a forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. It up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. It induces apoptosis in cell culture and downregulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination (3).
    Gen-ID
    43740569
    UniProt
    P0DTC3
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