SARS-CoV-2 Spike Antikörper (B.1.1.7 - alpha, P681H)

Produktnummer ABIN6992311

Produktdetails anti-SARS-CoV-2 Spike Antikörper

Target: SARS-CoV-2 Spike

Bindungsspezifität: B.1.1.7 - alpha, P681H

Reaktivität: SARS Coronavirus-2 (SARS-CoV-2), SARS CoV-2 Alpha

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SARS-CoV-2 Spike Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Aufreinigung: SARS-CoV-2 UK Variant (B.1.1.7) Spike P681H antibody is affinity chromatography purified via peptide column.

Immunogen: Anti-SARS-CoV-2 UK Variant (B.1.1.7) Spike P681H antibody was raised against a peptide corresponding to 12 amino acids near the center of SARS-CoV-2 UK variant (B.1.1.7) Spike protein. The immunogen is located within 650-700 amino acids of SARS-CoV-2 UK variant (B.1.1.7) Spike protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1 μ,g/mL. Antibody validated: Western Blot in human samples. Anti-SARS-CoV-2 UK Variant (B.1.1.7) Spike P681H antibody can specifically detect SARS-CoV-2 UK Variant (B.1.1.7) Spike S1 protein, but not SARS-CoV-2 WT Spike S1 protein by ELISA. It can also detect mutant peptide (681H), but not WT peptide (681P). All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: SARS-CoV-2 UK Variant (B.1.1.7) Spike P681H antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: SARS-CoV-2 UK Variant (B.1.1.7) Spike P681H antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu SARS-CoV-2 Spike

Target: SARS-CoV-2 Spike

Abstract: SARS-CoV-2 Spike Produkte

Synonyme: E2 antikoerper, E2 glycoprotein precursor antikoerper, Surface Glycoprotein antikoerper, S antikoerper

Substanzklasse: Viral Protein

Hintergrund:

In September of 2020 a new lineage of SARS-CoV-2, known as B.1.1.7, was discovered in the United Kingdom. This lineage was found to have developed 14 lineage-specific amino acid replacements and 3 deletions prior to its discovery. The transmission of UK variant (B.1.1.7 lineage) was increased at least 50 % . Increased severity and higher death rate were also found in UK variant. UK variant will not affect the effectiveness of COVID19 vaccine. One of the mutations associated with this lineage is a N501Y in the spike protein of the virus. It is believed that this mutation is able to increase the spike protein's affinity for the host ACE2 receptor and it has been associated with increased infectivity and virulence. B.1.1.7 viruses have also been shown to have a P681H in the cleavage site of spike protein. This location is one of the residues that make up the furin cleavage site between S1 and S2 in spike protein.

Gen-ID: 43740568