GCK Antikörper
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- Target Alle GCK Antikörper anzeigen
- GCK (Glucokinase (Hexokinase 4) (GCK))
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser GCK Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Produktmerkmale
- Polyclonal Antibody
- Aufreinigung
- Antigen Affinity Purification
- Immunogen
- Recombinant Mouse Glucokinase protein
- Isotyp
- IgG
- Top Product
- Discover our top product GCK Primärantikörper
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- Applikationshinweise
- WB 1:1000-1:2000 IHC 1:100-1:200 IF 1:100-1:400
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS with 0.05 % Proclin300 and 50 % glycerol, pH 7.4.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- GCK (Glucokinase (Hexokinase 4) (GCK))
- Andere Bezeichnung
- GCK (GCK Produkte)
- Hintergrund
- Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
- Molekulargewicht
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Observed_MW: 52 kDa
Calculated_MW: 52 kDa
- UniProt
- P52792
- Pathways
- MAPK Signalweg, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Cellular Glucan Metabolic Process, Regulation of Carbohydrate Metabolic Process
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