Patched 1 Antikörper

Produktnummer ABIN7235487

Produktdetails anti-Patched 1 Antikörper

Target: Patched 1 (PTCH1)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Patched 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human PTCH1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Patched 1

Target: Patched 1 (PTCH1)

Andere Bezeichnung: PTCH1 (PTCH1 Produkte)

Synonyme: BCNS antikoerper, HPE7 antikoerper, NBCCS antikoerper, PTC antikoerper, PTC1 antikoerper, PTCH antikoerper, PTCH11 antikoerper, lep antikoerper, ptc1 antikoerper, ptc2 antikoerper, Ptch antikoerper, Ptch2 antikoerper, Ptc-1 antikoerper, XPtc1 antikoerper, patched antikoerper, patched1 antikoerper, A230106A15Rik antikoerper, Ptc antikoerper, Ptc1 antikoerper, mes antikoerper, patched 1 antikoerper, patched 1 L homeolog antikoerper, Protein patched homolog 1 antikoerper, PTCH1 antikoerper, ptch1 antikoerper, Ptch1 antikoerper, ptch1.L antikoerper, ptc-1 antikoerper

Hintergrund: This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

Molekulargewicht: 161 kDa

UniProt: Q13635

Pathways: Hedgehog Signalweg, Carbohydrate Homeostasis, Tube Formation