5330431N24Rik antikoerper, AI851877 antikoerper, ARTD11 antikoerper, HIN1L antikoerper, C12orf6 antikoerper, parp11 antikoerper, MGC82612 antikoerper, PARP11 antikoerper, RGD1561791 antikoerper, poly (ADP-ribose) polymerase family, member 11 antikoerper, poly(ADP-ribose) polymerase family member 11 antikoerper, poly(ADP-ribose) polymerase family member 11 S homeolog antikoerper, poly(ADP-ribose) polymerase family member 11 L homeolog antikoerper, Parp11 antikoerper, PARP11 antikoerper, parp11.S antikoerper, parp11.L antikoerper, parp11 antikoerper
Hintergrund
Poly(ADP-ribosylation) is a method of DNA damage-dependent posttranslational modification that helps to rescue injured proliferating cells from cell death. The PARP (poly(ADP-ribose) polymerase) proteins comprise a superfamily of enzymes that functionally modify histones and other nuclear proteins, thereby preventing cell death. PARPs use NAD+ as a substrate to catalytically transfer ADP-ribose residues onto protein acceptors, a process that, when repeated multiple times, leads to the formation of poly(ADPribose) chains on the protein.