HMGCS1 Antikörper

Produktnummer ABIN7239032

Produktdetails anti-HMGCS1 Antikörper

Target: HMGCS1 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (Soluble) (HMGCS1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HMGCS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Synthetic peptide of human HMGCS1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.4 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu HMGCS1

Target: HMGCS1 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 1 (Soluble) (HMGCS1))

Andere Bezeichnung: HMGCS1 (HMGCS1 Produkte)

Synonyme: HMGCS antikoerper, zgc:56481 antikoerper, B130032C06Rik antikoerper, 3-hydroxy-3-methylglutaryl-CoA synthase 1 antikoerper, 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) antikoerper, 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 antikoerper, 3-hydroxy-3-methylglutaryl coenzyme A synthase antikoerper, hydroxymethylglutaryl-CoA synthase antikoerper, 3-hydroxy-3-methylglutaryl-CoA synthase antikoerper, hydroxymethylglutaryl coenzyme A synthase antikoerper, 3-hydroxy-3-methylglutaryl-CoA synthase 1 S homeolog antikoerper, HMGCS1 antikoerper, hmgcs1 antikoerper, Hmgcs1 antikoerper, mvaS antikoerper, SAS2432 antikoerper, SZO_RS04705 antikoerper, SEQ_1109 antikoerper, NAEGRDRAFT_77778 antikoerper, hmgcs1.S antikoerper

Hintergrund: HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4.

Molekulargewicht: 57 kDa

NCBI Accession: NP_001091742

UniProt: Q01581

Pathways: Regulation of Lipid Metabolism by PPARalpha