HMGB4 Antikörper
-
- Target Alle HMGB4 Antikörper anzeigen
- HMGB4 (High Mobility Group Box 4 (HMGB4))
-
Reaktivität
- Human
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser HMGB4 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), ELISA
- Produktmerkmale
- Polyclonal Antibody
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant protein of human HMGB4
- Isotyp
- IgG
- Top Product
- Discover our top product HMGB4 Primärantikörper
-
-
- Applikationshinweise
- WB 1:200-1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 0.2 mg/mL
- Buffer
- PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
-
- Target
- HMGB4 (High Mobility Group Box 4 (HMGB4))
- Andere Bezeichnung
- HMGB4 (HMGB4 Produkte)
- Synonyme
- HMGB4 antikoerper, dJ1007G16.5 antikoerper, 1700001F22Rik antikoerper, AI326135 antikoerper, high mobility group box 4 antikoerper, high-mobility group box 4 antikoerper, HMGB4 antikoerper, Hmgb4 antikoerper
- Hintergrund
- High mobility group protein B4is atranscription factorthat in humans is encoded by theHMGB4gene.HMGB4 is strongly and preferentially expressed in the adult mouse testis and weakly in the brain, but not in many other tissues. HMGB4 associates with chromatin, and in transfection assays, in contrast to HMGB1, it acts as a potent transcriptional repressor. During spermatogenesis, HMGB4 is present in the euchromatin of late pachytene spermatocytes and haploid round spermatids, whereas stronger expression is observed during the elongation phase, where it localizes to the basal pole of the nucleus in a manner mutually exclusive with H1FNT (H1T2) localized at the apical pole. HMGB4 basal localization is lost in H1FNT-mutant spermatids, showing that H1FNT provides a positional cue for organizing chromatin domains within the nucleus. These results show that HMGB4 and H1FNT specify distinct chromatin domains at the apical and basal poles of the elongating spermatid nucleus.
- Molekulargewicht
- 22 kDa
- UniProt
- Q8WW32
-