RNF144B Antikörper

Produktnummer ABIN7241528

Produktdetails anti-RNF144B Antikörper

Target: RNF144B (Ring Finger Protein 144B (RNF144B))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RNF144B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Recombinant protein of human RNF144B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:200-1:1000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.4 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu RNF144B

Target: RNF144B (Ring Finger Protein 144B (RNF144B))

Andere Bezeichnung: p53RFP (RNF144B Produkte)

Synonyme: IBRDC2 antikoerper, PIR2 antikoerper, bA528A10.3 antikoerper, p53RFP antikoerper, BC025007 antikoerper, E130105P19Rik antikoerper, Ibrdc2 antikoerper, Pir2 antikoerper, ring finger protein 144B antikoerper, RNF144B antikoerper, Rnf144b antikoerper

Hintergrund: P53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wildtype p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. Another p53 target protein is the p53-inducible RING finger protein (p53RFP), an auto-ubiquitinylated protein acting as an E3 ubiquitin ligase. p53RFP, also designated IBRDC2 in mouse and rat, receives ubiquitin from specific E2 ubiquitin-conjugating enzymes and transfers it to substrates that promote their degradation by the proteasome. p53RFP may mediate re-entry into the cell cycle.

Molekulargewicht: 34 kDa

UniProt: Q7Z419