Cullin 2 Antikörper

Produktnummer ABIN7242053

Produktdetails anti-Cullin 2 Antikörper

Target: Cullin 2 (CUL2)

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cullin 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Synthetic peptide of human CUL2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.6 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Cullin 2

Target: Cullin 2 (CUL2)

Andere Bezeichnung: CUL2 (CUL2 Produkte)

Synonyme: cul2 antikoerper, Cullin-2 antikoerper, fj48a06 antikoerper, wu:fj48a06 antikoerper, cullin-2 antikoerper, LOC100221330 antikoerper, 1300003D18Rik antikoerper, 4932411N15Rik antikoerper, AI327301 antikoerper, mKIAA4106 antikoerper, ATCUL2 antikoerper, F22D16.2 antikoerper, F22D16_2 antikoerper, cullin 2 antikoerper, cullin 2 antikoerper, cullin-2 antikoerper, putative cullin-2 (cul-2) antikoerper, cullin 2 L homeolog antikoerper, Cullin-2 antikoerper, cul2 antikoerper, CUL2 antikoerper, PTRG_05231 antikoerper, Smp_079740 antikoerper, LOC100550749 antikoerper, Cul2 antikoerper, cul2.L antikoerper, cul-2 antikoerper

Hintergrund: Human CUL2 is an ortholog of nematode cul2. Michel and Xiong (1998) identified human CUL2 cDNAs and reported that the predicted protein is 745 amino acids long.Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, whicHuman, Mouseediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 By similarity. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).

Molekulargewicht: 87 kDa

NCBI Accession: NP_003582

UniProt: Q13617

Pathways: M Phase, Asymmetric Protein Localization, SARS-CoV-2 Protein Interaktom