MCM4 Antikörper

Produktnummer ABIN7242281

Produktdetails anti-MCM4 Antikörper

Target: MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MCM4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Synthetic peptide of human MCM4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.3 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu MCM4

Target: MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))

Andere Bezeichnung: MCM4 (MCM4 Produkte)

Synonyme: cdc21 antikoerper, CDC21 antikoerper, CDC54 antikoerper, NKCD antikoerper, NKGCD antikoerper, P1-CDC21 antikoerper, hCdc21 antikoerper, 19G antikoerper, AI325074 antikoerper, AU045576 antikoerper, Cdc21 antikoerper, Mcmd4 antikoerper, mKIAA4003 antikoerper, mcdc21 antikoerper, cb1025 antikoerper, fc12c09 antikoerper, fj85g09 antikoerper, hm:zeh1616 antikoerper, wu:fc12c09 antikoerper, wu:fj85g09 antikoerper, zeh1616 antikoerper, minichromosome maintenance complex component 4 L homeolog antikoerper, minichromosome maintenance complex component 4 S homeolog antikoerper, minichromosome maintenance complex component 4 antikoerper, mcm4.L antikoerper, mcm4.S antikoerper, MCM4 antikoerper, mcm4 antikoerper, Mcm4 antikoerper

Hintergrund: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

Molekulargewicht: 97 kDa

NCBI Accession: NP_877423

UniProt: P33991

Pathways: DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA