NPRL2 Antikörper

Produktnummer ABIN7243658

Produktdetails anti-NPRL2 Antikörper

Target: NPRL2 (Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) (NPRL2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NPRL2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: Synthetic peptide of human NPRL2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.9 mg/mL

Buffer: PBS with 0.05 % sodium azide and 50 % glycerol, PH7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu NPRL2

Target: NPRL2 (Nitrogen Permease Regulator-Like 2 (S. Cerevisiae) (NPRL2))

Andere Bezeichnung: NPRL2 (NPRL2 Produkte)

Synonyme: 2810446G01Rik antikoerper, G21 antikoerper, NPR2L antikoerper, Tusc4 antikoerper, npr2 antikoerper, npr2l antikoerper, tusc4 antikoerper, NPR2 antikoerper, TUSC4 antikoerper, im:6900399 antikoerper, zgc:153630 antikoerper, nitrogen permease regulator-like 2 antikoerper, NPR2 like, GATOR1 complex subunit S homeolog antikoerper, NPR2 like, GATOR1 complex subunit antikoerper, NPR2-like, GATOR1 complex subunit antikoerper, Nprl2 antikoerper, nprl2.S antikoerper, NPRL2 antikoerper, nprl2 antikoerper

Hintergrund: NPRL2, also known as TUSC4 (tumor suppressor candidate 4), is a 380 amino acid protein that contains a bipartite nuclear localization signal and a granulin protein-binding domain. It is highly expressed in skeletal muscle, followed by brain, liver and pancreas, with lower expression in lung, kidney, placenta and heart. NPRL2 is also expressed in most lung cancer cell lines and may be involved in tumor suppression. NPRL2 may play a role in mismatch repair, cell cycle checkpoint signaling and activation of apoptotic pathways. It may also enhance the therapeutic efficacy of chemotherapy drugs such as cis-platin by resensitizing patients resistant to cisplatin treatment. The gene encoding NPRL2 is conserved between species and is expressed as two isoforms due to alternative splicing events.

NCBI Accession: NP_006536

UniProt: Q8WTW4