CG5127 antikoerper, Dmel\\CG5127 antikoerper, VPS33b antikoerper, Vps 33B antikoerper, dVps33B antikoerper, VPS33B antikoerper, GB11157 antikoerper, zgc:110803 antikoerper, Vacuolar protein sorting 33B antikoerper, VPS33B, late endosome and lysosome associated antikoerper, vacuolar protein sorting-associated protein 33B antikoerper, vacuolar protein sorting 33B antikoerper, Vps33B antikoerper, VPS33B antikoerper, LOC551135 antikoerper, Vps33b antikoerper, vps33b antikoerper
Hintergrund
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene is a member of the Sec-1 domain family, and encodes the human ortholog of rat Vps33b which is homologous to the yeast class C Vps33 protein. The mammalian class C vacuolar protein sorting proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Mutations in this gene are associated with arthrogryposis-renal dysfunction-cholestasis syndrome. Alternative splicing results in multiple transcript variants.