ABC30 antikoerper, CMOAT antikoerper, DJS antikoerper, MRP2 antikoerper, cMRP antikoerper, AI173996 antikoerper, Abc30 antikoerper, Cmoat antikoerper, Mrp2 antikoerper, ATP binding cassette subfamily C member 2 antikoerper, ATP-binding cassette, sub-family C (CFTR/MRP), member 2 antikoerper, ABCC2 antikoerper, Abcc2 antikoerper
Hintergrund
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine, therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.