SLC7A11 antikoerper, DKFZp468E122 antikoerper, CCBR1 antikoerper, xCT antikoerper, 9930009M05Rik antikoerper, AI451155 antikoerper, sut antikoerper, solute carrier family 7 member 11 antikoerper, solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 antikoerper, solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 antikoerper, SLC7A11 antikoerper, Slc7a11 antikoerper
Hintergrund
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.