Shootin-1 (SHTN1) Antikörper
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- Target Alle Shootin-1 (SHTN1) Antikörper anzeigen
- Shootin-1 (SHTN1)
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Produktmerkmale
- Polyclonal Antibody
- Aufreinigung
- Antigen affinity purification
- Immunogen
- Synthetic peptide of human SHTN1
- Isotyp
- IgG
- Top Product
- Discover our top product SHTN1 Primärantikörper
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- Applikationshinweise
- WB 1:500-1:2000, IHC 1:50-1:100, ELISA 1:5000-1:10000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 0.78 mg/mL
- Buffer
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- Shootin-1 (SHTN1)
- Andere Bezeichnung
- SHTN1 (SHTN1 Produkte)
- Synonyme
- Kiaa1598 antikoerper, Shootin1 antikoerper, mKIAA1598 antikoerper, shootin 1 antikoerper, SHTN1 antikoerper, Shtn1 antikoerper
- Hintergrund
- Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons.
- Molekulargewicht
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Observed_MW: Refer to figures
Calculated_MW: 72 kDa
- UniProt
- A0MZ66
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