tmx3 antikoerper, pdia13 antikoerper, txndc10 antikoerper, txndc10a antikoerper, TXNDC10 antikoerper, zgc:110025 antikoerper, txndc10b antikoerper, DKFZp469P2316 antikoerper, PDIA13 antikoerper, 6430411B10Rik antikoerper, A730024F05Rik antikoerper, AV259382 antikoerper, Txndc10 antikoerper, mKIAA1830 antikoerper, thioredoxin-related transmembrane protein 3 S homeolog antikoerper, thioredoxin related transmembrane protein 3 antikoerper, thioredoxin related transmembrane protein 3a antikoerper, thioredoxin-related transmembrane protein 3 L homeolog antikoerper, thioredoxin-related transmembrane protein 3 antikoerper, tmx3.S antikoerper, TMX3 antikoerper, tmx3a antikoerper, tmx3.L antikoerper, tmx3 antikoerper, Tmx3 antikoerper
Hintergrund
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The canonical protein encoded by this gene has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, one transmembrane domain and a C-terminal ER-retention sequence. This gene is expressed in many tissues but has its highest expression in heart and skeletal muscle. It is expressed in the retinal neuroepithelium and lens epithelium in the developing murine eye and haploinsufficiency of this gene in humans and zebrafish is associated with microphthalmia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.