FGFR4 Antikörper

Produktnummer ABIN7248038

Produktdetails anti-FGFR4 Antikörper

Target: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FGFR4 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Antigen affinity purification

Immunogen: Synthetic peptide of human FGFR4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:10-1:50, ELISA 1:5000-1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.72 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu FGFR4

Target: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Andere Bezeichnung: FGFR4 (FGFR4 Produkte)

Synonyme: FGFR4 antikoerper, XFGFR-4 antikoerper, XFGFR-4a antikoerper, cd334 antikoerper, fgfr-4 antikoerper, jtk2 antikoerper, tkf antikoerper, xfgfr4 antikoerper, CD334 antikoerper, JTK2 antikoerper, TKF antikoerper, Fgfr-4 antikoerper, etID309818.21 antikoerper, wu:fc13h10 antikoerper, zgc:111935 antikoerper, fgfr-4c antikoerper, fgfr4 antikoerper, fibroblast growth factor receptor 4 antikoerper, fibroblast growth factor receptor 4 S homeolog antikoerper, FGFR4 antikoerper, fgfr4 antikoerper, Fgfr4 antikoerper, fgfr4.S antikoerper

Hintergrund: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. FGFR4 (Fibroblast Growth Factor Receptor 4) is a Protein Coding gene. Diseases associated with FGFR4 include Prostate Cancer and Neuroma. Among its related pathways are GPCR Pathway and RET signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FGFR3.

UniProt: P22455

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Carbohydrate Homeostasis, Growth Factor Binding