MOB2 Antikörper

Produktnummer ABIN7248908

Produktdetails anti-MOB2 Antikörper

Target: MOB2 (MOB Kinase Activator 2 (MOB2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MOB2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Antigen affinity purification

Immunogen: Synthetic peptide of human MOB2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:40-1:200, ELISA 1:5000-1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.08 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu MOB2

Target: MOB2 (MOB Kinase Activator 2 (MOB2))

Andere Bezeichnung: MOB2 (MOB2 Produkte)

Synonyme: HCCA2 antikoerper, 1110017M21Rik antikoerper, 2700078K21Rik antikoerper, AI256456 antikoerper, Mmh antikoerper, Hcca2 antikoerper, RGD1562983 antikoerper, hcca2 antikoerper, mob2 antikoerper, mob2.1 antikoerper, p5a5 antikoerper, Mob2 antikoerper, MOB kinase activator 2 antikoerper, MOB kinase activator 2 L homeolog antikoerper, multigenic obesity QTL 2 antikoerper, MOB2 antikoerper, Mob2 antikoerper, mob2.1.L antikoerper, Mobq2 antikoerper

Hintergrund: MOB2 (Mps one binder kinase activator-like 2), also known as HCCA2 (Hepatocellular carcinoma-associated gene 2), is a 467 amino acid protein that belongs to the MOB1/phocein family. MOB2 is expressed in lung, spleen, brain, and fetal liver. It is highly expressed in hepatocellular carcinoma. MOB2 is localized in the perinuclear region of the cytoplasm in liver cancer tissues and colocalizes with MAD2L2 in the nucleus of Hela cells. MOB2 is characterized by two N-glycosylation sites, six N-myristolylation sites, two Src homology 3 (SH3), and several phosphorylation motifs which indicate that this protein may play a role in an intracellular signal transduction cascade. MOB2 binds to and regulates the autophosphorylation of the related human serine/threonine kinase 38 (NDR1) and serine/threonine kinase 38L(NDR2). It has been shown that MOB2 plays a critical role in cell cycle regulation. Overexpression of the protein during the G0/G1 phase inhibits cell proliferation causing cell cycle arrest. Stimulates the autophosphorylation and kinase activity of STK38 and STK38L.

UniProt: Q70IA6