Glutathione Peroxidase 1 Antikörper

Produktnummer ABIN7249606

Produktdetails anti-Glutathione Peroxidase 1 Antikörper

Target: Glutathione Peroxidase 1 (GPX1)

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Glutathione Peroxidase 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse GPX1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 400 μg/mL

Buffer: PBS with 0.02 % sodium azide, 1 % BSA and 50 % glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Glutathione Peroxidase 1

Target: Glutathione Peroxidase 1 (GPX1)

Andere Bezeichnung: GPX1 (GPX1 Produkte)

Synonyme: Gpx antikoerper, ATGPX1 antikoerper, F13D4.40 antikoerper, F13D4_40 antikoerper, GLUTATHIONE PEROXIDASE 1 antikoerper, glutathione peroxidase 1 antikoerper, gshpx1 antikoerper, AI195024 antikoerper, AL033363 antikoerper, CGPx antikoerper, GPx-1 antikoerper, GSHPx-1 antikoerper, GPX1 antikoerper, gpx1 antikoerper, cb690 antikoerper, zgc:92737 antikoerper, zgc:103683 antikoerper, GPXD antikoerper, GSHPX1 antikoerper, GSHPx antikoerper, wu:fd42f12 antikoerper, wu:fj22d06 antikoerper, zgc:101700 antikoerper, glutathione peroxidase Gpx1 antikoerper, glutathione peroxidase antikoerper, glutathione peroxidase 1 antikoerper, glutathione peroxidase 1a antikoerper, glutathione peroxidase family protein antikoerper, proliferating cell nuclear antigen antikoerper, glutathione peroxidase 1b antikoerper, glutathione peroxidase 1 S homeolog antikoerper, gpx1 antikoerper, GPX1 antikoerper, gpx antikoerper, Gpx antikoerper, Gpx1 antikoerper, gpx1a antikoerper, POPTR_0003s12620g antikoerper, Pcna antikoerper, LBL_RS00590 antikoerper, btuE-1 antikoerper, GPX2 antikoerper, gpx1b antikoerper, gpx1.S antikoerper

Hintergrund: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance, therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5 or 6 repeats have been found in the human population. The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women. Alternatively spliced transcript variants have been found for this gene. Pseudogenes of this locus have been identified on chromosomes X and 21.

Molekulargewicht:

Observed_MW: 22 kDa

Calculated_MW: 22 kDa

UniProt: P11352, P04041

Pathways: Thyroid Hormone Synthesis, Sensory Perception of Sound, Skeletal Muscle Fiber Development, Cell RedoxHomeostasis, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interaktom