PIN1 Antikörper (AA 56-163) (HRP)
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- Target Alle PIN1 Antikörper anzeigen
- PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
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Bindungsspezifität
- AA 56-163
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PIN1 Antikörper ist konjugiert mit HRP
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Homologie
- Human,Mouse,Rat,Dog,Sheep,Pig,Horse
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human Pin1
- Isotyp
- IgG
- Top Product
- Discover our top product PIN1 Primärantikörper
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- Applikationshinweise
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handhabung
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
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- Target
- PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
- Andere Bezeichnung
- Pin1 (PIN1 Produkte)
- Synonyme
- DOD antikoerper, UBL5 antikoerper, dod antikoerper, ubl5 antikoerper, pin1 antikoerper, pin1a antikoerper, 0610025L01Rik antikoerper, D9Bwg1161e antikoerper, pin1b antikoerper, zgc:73206 antikoerper, PPIase pin1 antikoerper, MdPin1 antikoerper, Pin1 antikoerper, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 antikoerper, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 S homeolog antikoerper, protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 antikoerper, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 L homeolog antikoerper, peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antikoerper, peptidyl-prolyl cis-trans isomerase Pin1 antikoerper, PIN1 antikoerper, Pin1 antikoerper, pin1 antikoerper, pin1.S antikoerper, pin1.L antikoerper, ppiD antikoerper, PITG_11123 antikoerper, LOC103419188 antikoerper
- Hintergrund
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Synonyms: DOD, NIMA interacting 1, Peptidyl prolyl cis trans isomerase NIMA interacting 1, Peptidyl prolyl cis/trans isomerase NIMA interacting, Pin 1, PPIase Pin1, Prolyl isomerase, Protein peptidylprolyl cis/trans isomerase NIMA interacting 1, Protein NIMA interacting 1, Rotamase Pin1, UBL 5, UBL5, PIN1_HUMAN.
Background: Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds. Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.
- Gen-ID
- 5300
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