NBR1 Antikörper

Produktnummer ABIN7250371

Produktdetails anti-NBR1 Antikörper

Target: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NBR1 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktmerkmale: Monoclonal Antibody

Aufreinigung: Protein A purification

Immunogen: Recombinant Protein of NBR1

Klon: 4C6

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-300, IF 1:50-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.4.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu NBR1

Target: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Andere Bezeichnung: NBR1 (NBR1 Produkte)

Synonyme: fa99f08 antikoerper, wu:fa99f08 antikoerper, MGC69008 antikoerper, NBR1 antikoerper, 1A1-3B antikoerper, M17S2 antikoerper, mKIAA0049 antikoerper, Ca125 antikoerper, RGD1311421 antikoerper, neighbor of brca1 gene 1a antikoerper, neighbor of BRCA1 gene 1 L homeolog antikoerper, NBR1, autophagy cargo receptor antikoerper, neighbor of Brca1 gene 1 antikoerper, nbr1a antikoerper, nbr1.L antikoerper, NBR1 antikoerper, Nbr1 antikoerper

Hintergrund: The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants.NBR1 (NBR1, Autophagy Cargo Receptor) is a Protein Coding gene. Diseases associated with NBR1 include Inclusion Body Myositis and Synucleinopathy. Among its related pathways are Mitophagy - animal. GO annotations related to this gene include ubiquitin binding and mitogen-activated protein kinase binding.

UniProt: Q14596

Pathways: Autophagie