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MLKL Antikörper (pSer358)

MLKL Reaktivität: Human IHC (p) Wirt: Maus Monoclonal 6E3 unconjugated
Produktnummer ABIN7250983
  • Target Alle MLKL Antikörper anzeigen
    MLKL (Mixed Lineage Kinase Domain-Like (MLKL))
    Bindungsspezifität
    • 11
    • 10
    • 10
    • 9
    • 7
    • 7
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer358
    Reaktivität
    • 55
    • 40
    • 17
    • 1
    • 1
    Human
    Wirt
    • 68
    • 6
    Maus
    Klonalität
    • 61
    • 13
    Monoklonal
    Konjugat
    • 32
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    Dieser MLKL Antikörper ist unkonjugiert
    Applikation
    • 33
    • 29
    • 14
    • 11
    • 5
    • 5
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Produktmerkmale
    Phosphorylated antibody
    Aufreinigung
    Protein A purification
    Immunogen
    Synthetic Peptide of Phospho-MLKL (Ser358)
    Klon
    6E3
    Isotyp
    IgG
    Top Product
    Discover our top product MLKL Primärantikörper
  • Applikationshinweise
    IHC 1:100-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 0.5 % BSA and 50 % glycerol, pH 7.4
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    MLKL (Mixed Lineage Kinase Domain-Like (MLKL))
    Andere Bezeichnung
    MLKL (MLKL Produkte)
    Synonyme
    MLKL antikoerper, 9130019I15Rik antikoerper, mixed lineage kinase domain like pseudokinase antikoerper, mixed lineage kinase domain-like antikoerper, MLKL antikoerper, mlkl antikoerper, Mlkl antikoerper
    Hintergrund
    This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain, however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.MLKL (Mixed Lineage Kinase Domain Like Pseudokinase) is a Protein Coding gene. Among its related pathways are Apoptosis and Autophagy and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity.
    UniProt
    Q8NB16
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