FNDC3B Antikörper

Produktnummer ABIN7252033

Produktdetails anti-FNDC3B Antikörper

Target: FNDC3B (Fibronectin Type III Domain Containing 3B (FNDC3B))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FNDC3B Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Antigen affinity purification

Immunogen: Full length fusion protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:30-1:150, ELISA 1:5000-1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.8 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu FNDC3B

Target: FNDC3B (Fibronectin Type III Domain Containing 3B (FNDC3B))

Andere Bezeichnung: FNDC3B (FNDC3B Produkte)

Synonyme: FAD104 antikoerper, PRO4979 antikoerper, YVTM2421 antikoerper, 1600019O04Rik antikoerper, AW550168 antikoerper, Fad104 antikoerper, mKIAA4164 antikoerper, RGD1311673 antikoerper, FNDC3B antikoerper, DKFZp469D136 antikoerper, fibronectin type III domain containing 3B antikoerper, FNDC3B antikoerper, Fndc3b antikoerper, fndc3b antikoerper

Hintergrund: Adipogenesis, the process of transforming pre-adipocytes into mature fat cells, is of particular interest due to the role adipocytes play in obesity and type II diabetes. Adipocytes have been shown to affect a variety of functions, including hemostasis, angiogenesis and energy balance, by secreting hormones and bioactive peptides. The FNDC3B protein, also designated FAD104 (factor for adipocyte differentiation 104) or HCV NS5A-binding protein 37, is expressed during early adipogenesis. Belonging to the FNDC3 family of proteins, FNDC3B is a 1,204 amino acid protein that contains nine fibronectin type-III domains. FNDC3B-deficient mice die within one day of birth, suggesting that FNDC3B is crucial for postpartum survival. Mouse embryonic fibroblasts (MEFs) with loss of FNDC3B function displayed a reduction in stress fiber formation, indicating a role for FNDC3B in cell proliferation, adhesion, spreading and migration.

UniProt: Q53EP0

Pathways: Positive Regulation of fat Cell Differentiation