CEP57 Antikörper

Produktnummer ABIN7252420

Produktdetails anti-CEP57 Antikörper

Target: CEP57 (Centrosomal Protein 57kDa (CEP57))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CEP57 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Antigen affinity purification

Immunogen: Full length fusion protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.4 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu CEP57

Target: CEP57 (Centrosomal Protein 57kDa (CEP57))

Andere Bezeichnung: CEP57 (CEP57 Produkte)

Synonyme: 3110002L15RIK antikoerper, CEP57 antikoerper, cep57r antikoerper, xCep57 antikoerper, c6orf182 antikoerper, 3110002l15rik antikoerper, RGD1309884 antikoerper, 3110002L15Rik antikoerper, 4921510P06Rik antikoerper, 4931428M20Rik antikoerper, AI467480 antikoerper, Tsp57 antikoerper, mKIAA0092 antikoerper, MVA2 antikoerper, PIG8 antikoerper, TSP57 antikoerper, centrosomal protein 57 antikoerper, centrosomal protein 57kDa-like 1 antikoerper, CEP57 antikoerper, cep57l1 antikoerper, Cep57 antikoerper

Hintergrund: This gene encodes a cytoplasmic protein called Translokin. This protein localizes to the centrosome and has a function in microtubular stabilization. The N-terminal half of this protein is required for its centrosome localization and for its multimerization, and the C-terminal half is required for nucleating, bundling and anchoring microtubules to the centrosomes. This protein specifically interacts with fibroblast growth factor 2 (FGF2), sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B, and thus mediates the nuclear translocation and mitogenic activity of the FGF2. It also interacts with cyclin D1 and controls nucleocytoplasmic distribution of the cyclin D1 in quiescent cells. This protein is crucial for maintaining correct chromosomal number during cell division. Mutations in this gene cause mosaic variegated aneuploidy syndrome, a rare autosomal recessive disorder. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Molekulargewicht:

Observed_MW: Refer to figures

Calculated_MW: 57 kDa

UniProt: Q86XR8

Pathways: M Phase, Maintenance of Protein Location, Protein targeting to Nucleus, Growth Factor Binding