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HLA-DMB Antikörper

HLA-DMB Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7252477
  • Target Alle HLA-DMB Antikörper anzeigen
    HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))
    Reaktivität
    • 42
    • 1
    Human
    Wirt
    • 39
    • 3
    Kaninchen
    Klonalität
    • 38
    • 4
    Polyklonal
    Konjugat
    • 22
    • 4
    • 4
    • 4
    • 4
    • 4
    Dieser HLA-DMB Antikörper ist unkonjugiert
    Applikation
    • 41
    • 30
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Produktmerkmale
    Polyclonal Antibody
    Aufreinigung
    Antigen affinity purification
    Immunogen
    Fusion protein of human HLA-DMB
    Isotyp
    IgG
    Top Product
    Discover our top product HLA-DMB Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.38 mg/mL
    Buffer
    PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))
    Andere Bezeichnung
    HLA-DMB (HLA-DMB Produkte)
    Synonyme
    RING7 antikoerper, D6S221E antikoerper, RT1.DMb antikoerper, RT1.Mb antikoerper, MHC-DMB antikoerper, major histocompatibility complex, class II, DM beta antikoerper, RT1 class II, locus DMb antikoerper, HLA-DMB antikoerper, RT1-DMb antikoerper, PATR-DMB antikoerper
    Hintergrund
    HLA-DMB (Major Histocompatibility Complex, Class II, DM Beta) is a Protein Coding gene. Diseases associated with HLA-DMB include Red-Green Color Blindness and Red Color Blindness. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include MHC class II protein complex binding. An important paralog of this gene is ENSG00000248993.HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
    Molekulargewicht

    Observed_MW: Refer to figures

    Calculated_MW: 29 kDa

    UniProt
    P28068
    Pathways
    Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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