GRG6 antikoerper, 1810057E06Rik antikoerper, Grg6 antikoerper, transducin like enhancer of split 6 antikoerper, transducin-like enhancer of split 6 antikoerper, TLE6 antikoerper, Tle6 antikoerper
Hintergrund
This gene encodes a member of the Groucho/ transducin-like Enhancer of split family of transcriptional co-repressors. The encoded protein is a component of the mammalian subcortical maternal complex, which is required for preimplantation development. In mouse, knock out of this gene results in cleavage-stage embryonic arrest resulting from defective cytoplasmic F-actin meshwork formation and asymmetric cell division. In human, an allelic variant in this gene is associated with preimplantation embryonic lethality. Alternative splicing results in multiple transcript variants.