NGEF Antikörper

Produktnummer ABIN7252975

Produktdetails anti-NGEF Antikörper

Target: NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NGEF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Antigen affinity purification

Immunogen: Fusion protein of human NGEF

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.6 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu NGEF

Target: NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))

Andere Bezeichnung: NGEF (NGEF Produkte)

Synonyme: Ephexin-1 antikoerper, ARHGEF27 antikoerper, EPHEXIN antikoerper, Tims2 antikoerper, ephexin antikoerper, Besh3 antikoerper, ephexin-1 antikoerper, neuronal guanine nucleotide exchange factor antikoerper, NGEF antikoerper, Ngef antikoerper

Hintergrund: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).

Molekulargewicht:

Observed_MW: Refer to figures

Calculated_MW: 82 kDa

UniProt: Q8N5V2

Pathways: Neurotrophin Signalübertragung