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Myogenin Antikörper

MYOG Reaktivität: Human, Maus, Ratte, Schwein, Rind (Kuh), Huhn WB, IHC (p), IF (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN700660
  • Target Alle Myogenin (MYOG) Antikörper anzeigen
    Myogenin (MYOG) (Myogenin (Myogenic Factor 4) (MYOG))
    Reaktivität
    • 114
    • 85
    • 58
    • 39
    • 29
    • 14
    • 12
    • 11
    Human, Maus, Ratte, Schwein, Rind (Kuh), Huhn
    Wirt
    • 72
    • 60
    • 1
    Kaninchen
    Klonalität
    • 72
    • 61
    Polyklonal
    Konjugat
    • 61
    • 10
    • 10
    • 9
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Myogenin Antikörper ist unkonjugiert
    Applikation
    • 97
    • 74
    • 34
    • 30
    • 30
    • 20
    • 13
    • 12
    • 10
    • 5
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Rind (Kuh), Human, Maus, Ratte
    Homologie
    Pig
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MYOG/Myogenin
    Isotyp
    IgG
    Top Product
    Discover our top product MYOG Primärantikörper
  • Applikationshinweise
    WB(1:100-500)
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    Myogenin (MYOG) (Myogenin (Myogenic Factor 4) (MYOG))
    Andere Bezeichnung
    Myogenin (MYOG Produkte)
    Synonyme
    cb553 antikoerper, zgc:100763 antikoerper, LOC446037 antikoerper, myf4 antikoerper, Xmyog antikoerper, myogenin antikoerper, LOC100136471 antikoerper, LOC100224062 antikoerper, LOC100303673 antikoerper, MYF4 antikoerper, bHLHc3 antikoerper, myo antikoerper, myf-4 antikoerper, myogenin antikoerper, myogenin (myogenic factor 4) antikoerper, MYOG antikoerper, myog antikoerper, LOC100303673 antikoerper, Myog antikoerper
    Hintergrund

    Synonyms: MYF4, myf-4, bHLHc3, Myogenin, Class C basic helix-loop-helix protein 3, Myogenic factor 4, MYOG

    Background: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth, phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts (By similarity).

    Molekulargewicht
    25kDa
    Gen-ID
    4656
    UniProt
    P15173
    Pathways
    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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