SETDB1 Antikörper

Produktnummer ABIN7253431

Produktdetails anti-SETDB1 Antikörper

Target: SETDB1 (SET Domain, Bifurcated 1 (SETDB1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SETDB1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Antigen affinity purification

Immunogen: Fusion protein of human SETDB1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-1:300, ELISA 1:5000-1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.08 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu SETDB1

Target: SETDB1 (SET Domain, Bifurcated 1 (SETDB1))

Andere Bezeichnung: SETDB1 (SETDB1 Produkte)

Synonyme: ESET antikoerper, H3-K9-HMTase4 antikoerper, KG1T antikoerper, KMT1E antikoerper, TDRD21 antikoerper, AU022152 antikoerper, mKIAA0067 antikoerper, SETDB1 antikoerper, NV10069 antikoerper, fc07d03 antikoerper, si:ch211-81a5.6 antikoerper, wu:fc07d03 antikoerper, im:7143091 antikoerper, wu:fa04a12 antikoerper, wu:fj80h02 antikoerper, zgc:152899 antikoerper, SET domain bifurcated 1 antikoerper, SET domain, bifurcated 1 antikoerper, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 antikoerper, histone-lysine N-methyltransferase SETDB1 antikoerper, SET domain, bifurcated 1a antikoerper, SET domain bifurcated 1 L homeolog antikoerper, SET domain, bifurcated 1b antikoerper, SETDB1 antikoerper, Setdb1 antikoerper, MLLT11 antikoerper, LOC100120014 antikoerper, LOC100461671 antikoerper, setdb1a antikoerper, setdb1.L antikoerper, setdb1b antikoerper

Hintergrund: SETDB1,also named as ESET,KIAA0067 and KMT1E,belongs to the histone-lysine methyltransferase family. It is a SET domain protein with histone H3-K9-specific methyltransferase activity. H3 'Lys-9' trimethylation is coordinated with DNA methylation and represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1,CBX3 and/or CBX5) proteins to methylated histones. SETDB1 mainly functions in euchromatin regions,thereby playing a central role in the silencing of euchromatic genes. It probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 regulates histone methylation,gene silencing,and transcriptional repression. It has been identified as a target for treatment in Huntington Disease,given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis.

UniProt: Q15047