FEN1 Antikörper
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- Target Alle FEN1 Antikörper anzeigen
- FEN1 (Flap Structure-Specific Endonuclease 1 (FEN1))
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser FEN1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Produktmerkmale
- Polyclonal Antibody
- Aufreinigung
- Affinity purification
- Immunogen
- Recombinant fusion protein of human FEN1 (NP_004102.1).
- Isotyp
- IgG
- Top Product
- Discover our top product FEN1 Primärantikörper
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anti-Flap Structure-Specific Endonuclease 1 (FEN1) antibody
FEN1 Reaktivität: Human WB, IHC, IF, IP, IHC (p), ICC, PLA Wirt: Kaninchen Polyclonal unconjugated
anti-Flap Structure-Specific Endonuclease 1 (FEN1) (AA 50-380) antibodyFEN1 Reaktivität: Human WB, IHC, IF, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Flap Structure-Specific Endonuclease 1 (FEN1) antibodyFEN1 Reaktivität: Human, Maus, Ratte WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Flap Structure-Specific Endonuclease 1 (FEN1) antibodyFEN1 Reaktivität: Human WB, IHC, ELISA, IF Wirt: Kaninchen Monoclonal 4D9 unconjugated Recombinant Antibody
anti-Flap Structure-Specific Endonuclease 1 (FEN1) (AA 243-272) antibodyFEN1 Reaktivität: Human WB, IF Wirt: Kaninchen Polyclonal RB17639 unconjugated
anti-Flap Structure-Specific Endonuclease 1 (FEN1) (AA 1-380) antibodyFEN1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-Flap Structure-Specific Endonuclease 1 (FEN1) (Internal Region) antibodyFEN1 Reaktivität: Human WB, IHC, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Flap Structure-Specific Endonuclease 1 (FEN1) (Internal Region) antibodyFEN1 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Flap Structure-Specific Endonuclease 1 (FEN1) antibodyFEN1 Reaktivität: Human, Maus WB, ICC Wirt: Maus Monoclonal unconjugated
anti-Flap Structure-Specific Endonuclease 1 (FEN1) antibodyFEN1 Reaktivität: Human, Maus WB, IP Wirt: Maus Monoclonal unconjugated
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- Applikationshinweise
- WB 1:500-1:2000 IHC 1:50-1:200 IF 1:10-1:100
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- FEN1 (Flap Structure-Specific Endonuclease 1 (FEN1))
- Andere Bezeichnung
- FEN1 (FEN1 Produkte)
- Hintergrund
- The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.
- Molekulargewicht
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Observed_MW: 48 kDa
Calculated_MW: 35 kDa/42 kDa
- Gen-ID
- 2237
- UniProt
- P39748
- Pathways
- Telomere Maintenance, DNA Reparatur, DNA Replication, Synthesis of DNA
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