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P-Glycoprotein Antikörper

Reaktivität: Human, Maus, Ratte IHC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7007615
  • Target Alle P-Glycoprotein Produkte
    P-Glycoprotein
    Reaktivität
    • 21
    • 9
    • 8
    • 2
    Human, Maus, Ratte
    Wirt
    • 15
    • 7
    Kaninchen
    Klonalität
    • 15
    • 6
    • 1
    Polyklonal
    Konjugat
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser P-Glycoprotein Antikörper ist unkonjugiert
    Applikation
    • 12
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Immunofluorescence (IF)
    Produktmerkmale
    Polyclonal Antibody
    Aufreinigung
    Affinity purification
    Immunogen
    A synthetic peptide of human P Glycoprotein (NP_000918.2).
    Isotyp
    IgG
  • Applikationshinweise
    IHC 1:50-1:200 IF 1:50-1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    P-Glycoprotein
    Andere Bezeichnung
    P Glycoprotein (P-Glycoprotein Produkte)
    Synonyme
    ABC20 antikoerper, CD243 antikoerper, CLCS antikoerper, GP170 antikoerper, MDR1 antikoerper, P-GP antikoerper, PGY1 antikoerper, Abcb1 antikoerper, Mdr1a antikoerper, ABCB1 antikoerper, ABCB4 antikoerper, CMDR1 antikoerper, xemdr antikoerper, ATP binding cassette subfamily B member 1 antikoerper, ATP binding cassette subfamily B member 1A antikoerper, ATP binding cassette subfamily B member 1 L homeolog antikoerper, ABCB1 antikoerper, Abcb1a antikoerper, abcb1.L antikoerper
    Hintergrund
    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
    Gen-ID
    5243
    UniProt
    P08183
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