P-Glycoprotein Antikörper
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- Target Alle P-Glycoprotein Produkte
- P-Glycoprotein
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser P-Glycoprotein Antikörper ist unkonjugiert
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Applikation
- Immunohistochemistry (IHC), Immunofluorescence (IF)
- Produktmerkmale
- Polyclonal Antibody
- Aufreinigung
- Affinity purification
- Immunogen
- A synthetic peptide of human P Glycoprotein (NP_000918.2).
- Isotyp
- IgG
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anti-P-Glycoprotein antibody
Reaktivität: Maus, Ratte WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-P-Glycoprotein antibodyReaktivität: Human WB, FACS, IP Wirt: Maus Monoclonal 17F9 unconjugated
anti-P-Glycoprotein (AA 647-677) antibodyReaktivität: Human WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-P-Glycoprotein (AA 647-677) antibodyReaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-P-Glycoprotein antibodyReaktivität: Human, Hamster WB, IHC, FACS, ICC Wirt: Maus Monoclonal JSB-1 unconjugated
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- Applikationshinweise
- IHC 1:50-1:200 IF 1:50-1:200
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- P-Glycoprotein
- Andere Bezeichnung
- P Glycoprotein (P-Glycoprotein Produkte)
- Hintergrund
- The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
- Gen-ID
- 5243
- UniProt
- P08183
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